Neurocrine Announces Promising Phase 3 Results for CAH Treatment

Published 1 days agoNBIX

Neurocrine Announces Promising Phase 3 Results for CAH Treatment

Neurocrine Biosciences has recently shared encouraging outcome from its Phase 3 CAHtalyst™ Adult Study, showcasing the long-term benefits of CRENESSITY™ (crinecerfont) for patients with classic congenital adrenal hyperplasia (CAH). The study reported significant reductions in daily glucocorticoid doses among participants taking crinecerfont, achieving a 27% decrease at 24 weeks, compared to only a 10% decrease in those on a placebo.

Furthermore, crinecerfont not only aided in glucocorticoid reduction but also successfully maintained control over androstenedione levels, an essential androgen. In a marked improvement, about 63% of crinecerfont recipients reached physiologic glucocorticoid doses (defined as ≤11 mg/m²/day), significantly outpacing the 18% achievement rate seen in the placebo cohort. The study also found crinecerfont to be generally well-tolerated, with common adverse effects including fatigue and headache.

These findings underline the potential role of crinecerfont as a pioneering treatment in CAH management. Reuters has reported that this data further supports its effectiveness and contributes to Neurocrine's broader strategy to offer innovative solutions in the treatment of genetic disorders, now awaiting FDA approval to bring these advancements to the market.

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