Vertex Pharmaceuticals saw its stock decline after reporting first-quarter 2025 earnings that fell short of expectations. The company reported an adjusted profit of $4.06 per share, missing analyst estimates of $4.32, as noted by Reuters. Coupled with this, total quarterly revenue rose 2.7% to $2.77 billion, which was below the anticipated $2.85 billion.
Sales of Trikafta, its flagship cystic fibrosis drug, increased 2% year-over-year to $2.53 billion, but did not meet forecasts of $2.58 billion. This contributed to a 2.5% drop in Vertex's stock price during after-hours trading. Despite these challenges, the company raised its 2025 revenue forecast's lower end to between $11.85 billion and $12 billion.
Vertex has been actively expanding its portfolio, launching the non-opioid pain medication Journavx in March, quickly gaining traction with over 20,000 prescriptions. Furthermore, the company reports advances with its gene therapy Casgevy for rare blood disorders, having activated more than 65 treatment centers and initiating cell collection for 90 patients.